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Experimental Data and PBPK Modeling Quantify Antibody Interference in PEGylated Drug Carrier Delivery

https://doi.org/10.1007/s11538-021-00950-z

Talkington, Anne M.; Wessler, Timothy; Lai, Samuel K.; Cao, Yanguang; Forest, M. Gregory (December 2021, Bulletin of Mathematical Biology)

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A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes

https://doi.org/10.1016/j.jconrel.2022.01.022

Talkington, Anne M.; McSweeney, Morgan D.; Wessler, Timothy; Rath, Marielle K.; Li, Zibo; Zhang, Tao; Yuan, Hong; Frank, Jonathan E.; Forest, M. Gregory; Cao, Yanguang; et al (March 2022, Journal of Controlled Release)

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Overcoming anti-PEG antibody mediated accelerated blood clearance of PEGylated liposomes by pre-infusion with high molecular weight free PEG

https://doi.org/10.1016/j.jconrel.2019.08.017

McSweeney, Morgan D.; Price, Lauren S.L.; Wessler, Timothy; Ciociola, Elizabeth C.; Herity, Leah B.; Piscitelli, Joseph A.; DeWalle, Alexander C.; Harris, Taylor N.; Chan, Andy K.P.; Saw, Ran Sing; et al (October 2019, Journal of Controlled Release)

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